Optimasi Formulasi Tablet Lepas Lambat Ekstrak Seledri (Apium graveolens L.) Menggunakan Polimer Xanthan Gum dan Lubrikan Magnesium Stearat dengan Metode Simplex Lattice Design (SLD)

Antihypertensive drugs undergo first-pass metabolism and therefore have low oral bioavailability. It causes an increase in the frequency of drug use concentration fluctuations that affect patient comfort. The sustained release tablet formulation was chosen because it can deliver active substance with good An antihypertensive be used is celery extract contains flavonoids, so a made using xanthan gum magnesium stearate to produce constant controlled rate. This study aims knowing results evaluation different concentrations stearate, also obtains optimal formulation. manufacture tablets uses direct compression method. Powder evaluations include flow property through funnel, angle repose, compressibility index, moisture content. Tablet organoleptic, weight uniformity, size hardness, friability, disintegration time, dissolution tests. data were analyzed Simplex Lattice Design. powder result all formulations meets requirements Physical shows meet requirement friability On uniformity test, do not requirement. time test show F1 does Meanwhile, F4 best formula Based on Design, most 52 mg 3 mg.